The zinc chelator, N,N,N′,N′-tetrakis (2-pyridylmethyl) ethylenediamine, increases the level of nonfunctional HIF-1α protein in normoxic cells
- 20 March 2006
- journal article
- Published by Elsevier in Biochemical and Biophysical Research Communications
- Vol. 343 (4) , 1002-1008
- https://doi.org/10.1016/j.bbrc.2006.03.039
Abstract
No abstract availableKeywords
This publication has 33 references indexed in Scilit:
- HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O2 levelsJournal of Cell Science, 2003
- A Conserved Family of Prolyl-4-Hydroxylases That Modify HIFScience, 2001
- C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl HydroxylationCell, 2001
- Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylationThe EMBO Journal, 2001
- Transcription Factor HIF-1 Is a Necessary Mediator of the Pasteur Effect in Mammalian CellsMolecular and Cellular Biology, 2001
- HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 SensingScience, 2001
- Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl HydroxylationScience, 2001
- Identification of the von Hippel–Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complexProceedings of the National Academy of Sciences, 1999
- Regulation of the Hypoxia-inducible Transcription Factor 1α by the Ubiquitin-Proteasome PathwayJournal of Biological Chemistry, 1999
- Regulation of hypoxia-inducible factor 1α is mediated by an O 2 -dependent degradation domain via the ubiquitin-proteasome pathwayProceedings of the National Academy of Sciences, 1998