Antibody to Genital Herpes Simplex Virus: Association With Cervical Atypia and CarcinomaIn Situ2

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Abstract
Multiplicity analyses using an artificial mixture of two strains of herpes simplex virus, a prototype of the genital strain (HSV-2) and a laboratory strain designated HSV-MP, were used to differentiate antibodies to the oral and genital strains of herpes simplex virus in sera from patients with cervical carcinoma. The studies indicate that the prevalence of antibodies to the genital variant of the virus was identical in patients with cytologically, histologically, and colposcopically confirmed atypia, carcinoma in situ, and invasive carcinoma. Statistically significant differences (P <0.0005) were observed between HSV-2 antibodies in these patients and a matched control population, differences which do not exist in two other venereally transmitted diseases. Epidemiologic evidence has long implicated a venereally transmitted factor in the etiology of cervical carcinoma. This investigation supports the hypothesis that genital herpes simplex virus may be responsible for the induction of squamous neoplasia in the human cervix.

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