Enhancement by Hyrazine Sulfate of Antitumor Effectiveness of Cytoxan, Mitomycin C, Methotrexate and Bleomycin, in Walker 256 Carcinosarcoma in Rats

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Abstract
Use of hydrazine sulfate potentiates the antitumor action of Cytoxan (cyclophosphamide), Mitomycin C, methotrexate and bleomycin against Walker 256 intramuscular carcinosarcoma in in vivo short-term studies in rats. Experimental data suggest this potentiation by hydrazine sulfate to result from a mechanism of action other than direct cytotoxicity, and further, that combination chemotherapy with hydrazine sulfate and a cytotoxic agent may be useful in the treatment of human cancer.