Effect of some hormones on the rate of the triacylglycerol/fatty-acid substrate cycle in adipose tissue of the mouse in vivo

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Abstract
A method is described for the measurement of the rate of the triacylglycerol/fatty-acid cycle in adipose tissue of the mouse in vivo, which depends on the incorporation of 3H from [3H]H2O into the glycerol and fatty-acid moieties of triacylglycerol. The rate of the cycling is increased 2-fold by feeding, an effect that is completely abolished by the .beta.-adrenergic blocker propranolol. The .beta.-adrenergic agonist fenoterol increased the rate of cycling 5-fold in white adipose tissue and 3-fold in brown adipose tissue. Cold exposure had no effect on the rate of cycling in white adipose tissue but increased the rate almost 2-fold in brown adipose tissue. The increased rate of cycling during feeding, which may be due to increased sympathetic nervous activity, is consistent with the view that the role of cycling is to increase sensitivity of metabolic control systems when required.