5"-Amino-3',4',5"-trideoxybutirosin A, a new semisynthetic aminoglycoside antibiotic.

1 January 1975

journal article
research article
Published by Japan Antibiotics Research Association in The Journal of Antibiotics

Vol. 28 (7) , 522-529
https://doi.org/10.7164/antibiotics.28.522

Abstract

5"-Amino-3'',4'',5"-trideoxybutirosin A (IX) was synthesized through a reaction series starting from 5"-amino-5"-deoxybutirosin A (Ic), the key step being the treatment of its tetra-O-acetylpentakis-N-[(phenylmethoxy)carbonyl]-3'',4''-bis-O-(methylsulfonyl) derivative with zinc-sodium iodide. Compound IX exhibits enhanced antibacterial activities, including strains of Pseudomonas aeruginosa and Escherichia coli which are highly resistant to Ic, butirosin or gentamicin.

This publication has 1 reference indexed in Scilit:

Action of zinc dust and sodium iodide in N,N-dimethylformamide on contiguous, secondary sulfonyloxy groups: a simple method for introducing nonterminal unsaturation
Carbohydrate Research, 1965