TOXIC EFFECTS OF INTRATHECAL ADMINISTRATION OF PENICILLIN
- 1 July 1947
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology & Psychiatry
- Vol. 58 (1) , 39-45
- https://doi.org/10.1001/archneurpsyc.1947.02300300049005
Abstract
Penicillin has been regarded as quite harmless even when administered in large doses and it is true that toxic manifestations are relatively rare as a result of parenteral administration. This is not the case when the drug is administered intrathecally, particularly if the dose is excessive. To illustrate this fact, which has not been generally recognized, two types of complications following intrathecal administration of penicillin are presented. EXPERIMENTAL BASIS In a series of experiments on the macaque monkey, on thirteen occasions 20,000 units of penicillin in 1 cc. of isotonic solution of sodium chloride was injected intrathecally. Within ten to fifteen minutes the animals were observed to look at, rub and then vigorously scratch their tails and perianal regions. This behavior persisted for at least an hour in some instances. In the monkey, these paresthesias appeared to be temporary, for the animal was well the following morning. The spinal cordsKeywords
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