Activity of rifampicin against staphylococci, with special reference to multiresistant strains
- 1 January 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 13 (suppl C) , 7-16
- https://doi.org/10.1093/jac/13.suppl_c.7
Abstract
Antibiotic-sensitive and multiply-resistant isolates of Staphylococcus aureus and Staph. epidermidis were all sensitive to rifampicin (MIC ⋜ 0.015 mg/l) and to novo-biocin, vancomycin and teicoplanin (MICs < 1 mg/l). No tolerance was observed. Resistance sometimes developed in bactericidal tests on rifampicin or novobiocin alone, but not with vancomycin or teicoplanin, or with combinations. The implications of these findings are discussed in the context of serious infections with staphylococci, especially those resistant to β -lactams and aminoglycosides.Keywords
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