Changes in Extrinsic Fluorescence in Squid Axons during Voltage-Clamp
- 25 September 1970
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 169 (3952) , 1322-1324
- https://doi.org/10.1126/science.169.3952.1322
Abstract
Fluorescence changes in squid axons were examined after staining with rhodamine B, pyronin B, or 8-anilinonaphthalene-1-sulfonate by intracellular application. Gradual changes in fluorescence were detected during both hyperpolarizing and depolarizing voltage-clamp pulses. Abrupt changes were often observed at the onset and at the end of voltage-clamp. Possible sources of artifact in optical measurements of this type and some implications of the findings are discussed.Keywords
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