INHIBITORY EFFECT OF GLUCAGON, SECRETIN AND CERULEIN ON GASTRIC-ACID SECRETION STIMULATED BY PENTAGASTRIN IN PATIENTS WITH DUODENAL-ULCER

  • 1 January 1978
    • journal article
    • research article
    • Vol. 25  (6) , 487-491
Abstract
In 10 duodenal ulcer patients, gastric acid secretion was stimulated by i.v. infusion of 1.5 .mu.g pentagastrin/kg h. When acid secretion had reached a plateau, glucagon in a dose of 30 .mu.g/kg h, sectetin in a dose of 1 IU/kg h or caerulein in a dose of 0.1 .mu.g/kg h were infused into a separate vein for 1 hour during the i.v. infusion of pentagastrin. Using these doses, each drug produced about 30% inhibition given separately. The highest degree of inhibition was obtained by the combination of glucagon and secretin. The inhibition reached the sum of the inhibitions after glucagon and secretin administered separately. Caerulein added to glucagon or secretin could slightly increase the inhibitory effect of these drugs given separately. Caerulein, failed to increase inhibition when glucagon and secretin were infused simultaneously.