Decreased ATPase and Increased Sodium Content of Platelets in Down's Syndrome

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Abstract
ATPase activity and sodium and potassium concentrations were studied in platelets from normal subjects and patients with Down's syndrome. Platelet ATPase activity of the patients was significantly decreased (p < 0.001 )-136.8 ± 5.2 (±S.E.M.) nm per hour per 108 platelets as compared to 173.2 ± 7.3 nm per hour per 108 normal platelets. Platelet potassium content of the patients was also decreased, 13.12 ± 0.48 μg per 109 platelets as compared to 19.78 ± 0.72 μg per 109 normal platelets (p < 0.001). Platelet sodium content of the patients was increased, 6.79 ± 0.40 μg per 109 platelets as compared to 3.32 ± 0.21 μg per 109 normal platelets (p < 0.001). The potassium-sodium ratios in the platelets of the patients had no overlap with values obtained in the normal controls.