Histidine Metabolic Loading Test to Distinguish Folic Acid Deficiency From Vit. B12 in Megaloblastic Anemias.
- 1 June 1959
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 101 (2) , 350-352
- https://doi.org/10.3181/00379727-101-24936
Abstract
1) A new procedure for diagnosis of clinical folic acid deficiency is described which distinguishes it from Vit. B12 deficiency. This permits differentiation of Addisonian pernicious anemia in relapse from megaloblastic anemia due to folic acid deficiency. 2) The procedure is based upon oral administration of 15 g of L-histidine monohydrochloride for 48–72 hours and measurement of urinary concentration or 24-hour excretion of formiminoglutamic acid, which accumulates in folic acid deficiency. Under these conditions, urine FIGLU levels do not exceed 30 γ/ml in non-folic acid deficient individuals; are 3 to 1000 fold greater in folic acid deficiency.Keywords
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