Expression of Lactate and Malate Dehydrogenases in Tumors Induced by SV40 and 7,12-Dimethylbenz( a )anthracene
- 6 October 1972
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 178 (4056) , 70-71
- https://doi.org/10.1126/science.178.4056.70
Abstract
Isozyme patterns of lactate and malate dehydrogenases were studied in tumors induced by SV40 and 7,12-dimethylbenz( a )anthracene and in established cultures of cells from these tumors. The expression of B polypeptide subunits of lactate dehydrogenase is suppressed similarly by both agents. This may be due to inactivation of the gene at the locus determining the B polypeptide subunit. Malate dehydrogenase isozyme patterns are not changed significantly by the virus or the carcinogen.Keywords
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