Resonant Cell Laser-Based Photoacoustic Densitometer for Thin-Layer Chromatography

Abstract
Photoacoustic spectroscopy was applied to the in situ densitometry of thin-layer chromatographic plates. Fast laser-scanning detection with signal enhancement was demonstrated at a resonant frequency of the cell. The use of phase difference between signal and background provided higher signal-to-noise ratios. Detection limit for Orange G was 170 pg, and the analytical curve was linear over three orders of magnitude.