Measles virus V protein blocks interferon (IFN)‐α/β but not IFN‐γ signaling by inhibiting STAT1 and STAT2 phosphorylation
Open Access
- 21 May 2003
- journal article
- Published by Wiley in FEBS Letters
- Vol. 545 (2-3) , 177-182
- https://doi.org/10.1016/s0014-5793(03)00528-3
Abstract
Measles virus (MV), a member of the family Paramyxoviridae, encodes C and V non‐structural proteins. To clarify the functions of MV C and V proteins, HeLa cell lines constitutively expressing C or V protein were established. We found that expression of V protein inhibited interferon (IFN)‐α/β signaling but not IFN‐γ signaling. C protein had no inhibitory effect on IFN signaling in our experimental condition. Degradation of selective signal transducers and activators of transcription (STAT) proteins was not observed in HeLa cells expressing V protein. In contrast, tyrosine phosphorylation of both STAT1 and STAT2 was inhibited in these cells after IFN‐β stimulation.Keywords
This publication has 60 references indexed in Scilit:
- Virus Replication in Engineered Human Cells That Do Not Respond to InterferonsJournal of Virology, 2003
- The p127 Subunit (DDB1) of the UV-DNA Damage Repair Binding Protein Is Essential for the Targeted Degradation of STAT1 by the V Protein of the Paramyxovirus Simian Virus 5Journal of Virology, 2002
- The Amino-Terminal Half of Sendai Virus C Protein Is Not Responsible for either Counteracting the Antiviral Action of Interferons or Down-Regulating Viral RNA SynthesisJournal of Virology, 2002
- STAT2 Acts as a Host Range Determinant for Species-Specific Paramyxovirus Interferon Antagonism and Simian Virus 5 ReplicationJournal of Virology, 2002
- Longer and Shorter Forms of Sendai Virus C Proteins Play Different Roles in Modulating the Cellular Antiviral ResponseJournal of Virology, 2001
- The virus battles: IFN induction of the antiviral state and mechanisms of viral evasionPublished by Elsevier ,2001
- C Terminal CYS-RICH Region of Mumps Virus Structural V Protein Correlates with Block of Interferon α and γ Signal Transduction Pathway through Decrease of STAT 1-αBiochemical and Biophysical Research Communications, 2001
- Single Amino Acid Substitution in the V Protein of Simian Virus 5 Differentiates Its Ability To Block Interferon Signaling in Human and Murine CellsJournal of Virology, 2001
- Knockout of the Sendai virus C gene eliminates the viral ability to prevent the interferon‐α/β‐mediated responsesFEBS Letters, 1999
- Poor induction of interferon-induced 2′,5′-oligoadenylate synthetase (2–5 AS) in cells persistently infected with mumps virus is caused by decrease of STAT-1αArchiv für die gesamte Virusforschung, 1998