First Synthetic Carbohydrates with the Full Anticoagulant Properties of Heparin
- 16 November 1998
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 37 (21) , 3009-3014
- https://doi.org/10.1002/(sici)1521-3773(19981116)37:21<3009::aid-anie3009>3.0.co;2-f
Abstract
A single disaccharide building block is required to obtain synthetic carbohydrates that reproduce the anticoagulant activity of heparin and inhibit thrombin (n>6) and/or factor Xa (n≥2; see reaction scheme). Thus, there is evidence that heparin fragments with at least 15 saccharide units are required for thrombin inhibition. Lev=levulinoyl.This publication has 0 references indexed in Scilit: