Treatment of Idiopathic Oligozoospermia by Kallikrein: Results of a Double-Blind Study
- 1 January 1979
- journal article
- clinical trial
- Published by Taylor & Francis in Archives of Andrology
- Vol. 2 (2) , 163-170
- https://doi.org/10.3109/01485017908987308
Abstract
Ninety subfertile men with idiopathic oligozoospermia were treated orally with either 600 units porcine pancreatic kallikrein or placebo daily for 7 wk. Kallikrein caused an increase in the number of spermatozoa (3.1 × 107) with a maximum 2-3 mo after onset of therapy. There was an improvement of the quantitative and qualitative sperm motility with a maximum at the end of treatment. Five months after onset of therapy, pretreatment values were regained. There were no major side effects. Conception rates within a period of 1 yr were 16% for placebo and 38% for kallikrein.Keywords
This publication has 3 references indexed in Scilit:
- Die Behandlung männlicher Fertilitätsstörungen mit Kallikrein*Deutsche Medizinische Wochenschrift (1946), 1976
- Occurrence of Components of the Kallikrein-Kinin System in Human Genital Tract Secretions and their Possible Function in Stimulation of Sperm Motility and MigrationPublished by Springer Nature ,1976
- Concentrations of angiotensin-converting enzyme in tissues of the ratBiochimica et Biophysica Acta (BBA) - Enzymology, 1971