Cell Mediated Lympholysis in Man. The Impact of HLA‐C Antigens
- 1 May 1976
- journal article
- research article
- Published by Wiley in Tissue Antigens
- Vol. 7 (5) , 301-309
- https://doi.org/10.1111/j.1399-0039.1976.tb01071.x
Abstract
From a population of individuals, all HLA‐A, B, and C tissue typed in relation to the Sixth International Histocompatibility Workshop, an experimental investigation has been performed to study the influence of the HLA‐Cw1, w2, w3, w4, and w5 antigens in the Cell Mediated Lympholysis (CML) test.The average cytolysis obtained due to allogenic attack of one HLA‐C antigen equals 12.6%, but like the HLA‐A and B antigens, HLA‐C antigens exhibit differences with regard to sensitizing and target potential. This indicates either a heterogeneity of these antigens or the existence of separate CML determinants.It is concluded that the HLA‐C antigens may account for the cytolysis observed in some of the combinations exhibiting cytolysis which cannot be explained by the HLA‐A and B antigens.This publication has 10 references indexed in Scilit:
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