Immuno-chemical Studies on the Alkali-labile Carbohydrate Chains of Human Serum Glycoproteins

Publisher Website
Google Scholar
Abstract
Human serum glycoproteins can be classified into those containing N-acetyl-D-galactosamine and those lacking this hexosamine. The N-acetyl-D-galactosamine-containing serum glycoproteins have alkali-labile chains containing this hexosamine linked O-glycosidically to hydroxy amino acids. These alkali-labile chains can be demonstrated in neuraminic acid free serum glycoproteins by GLC and by using precipitating lectins from invertebrates and plants. They are presented by 2 chains, 1 containing only N-acetyl-D-galactosamine, the other with D-galactose linked (1-3) .beta.-glycosidically to this hexosamine forming a disaccharide. Serologically these 2 chains, which usually occur together on 1 molecule, can be characterized by their reaction with lectins from Helix pomatia (anti-A like), Agaricus bisporus and Arachis hypogaea (anti-TF specificity).
Keywords

This publication has 4 references indexed in Scilit: