Application of 1,2,4-triazoline-3,5-diones in the synthesis of the piperazic acids (hexahydropyridazine-3-carboxylic acids)
- 1 January 1976
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 22,p. 2390-2394
- https://doi.org/10.1039/p19760002390
Abstract
Diels–Alder reactions between penta-2,4-dienoic acid (and substituted analogues) and 4-phenyl-1,2,4-triazoline-3,5-dione (or 1,2,4-triazoline-3,5-dione) give adducts which, after hydrogenation and hydrolysis, yield the piperazic acid residues identified in the hydrolysates of the monamycin series of cyclohexadepsipeptide antibiotics.This publication has 0 references indexed in Scilit: