The tetratricopeptide repeats of Ssn6 interact with the homeo domain of alpha 2.
- 1 December 1995
- journal article
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 9 (23) , 2903-2910
- https://doi.org/10.1101/gad.9.23.2903
Abstract
The tetratricopeptide repeat (TPR) is a 34-amino-acid degenerate sequence motif that is found in a large variety of proteins, both prokaryotic and eukaryotic. TPRs are usually found in tandem arrays of up to 16 copies. In this paper we identify a direct interaction between the TPRs of Ssn6, a general transcriptional repressor, and alpha 2, a cell-type regulator in Saccharomyces cerevisiae. Five of the Ssn6 TPRs were tested individually, and all were found to interact specifically with alpha 2. These results suggest a model for TPR-protein interactions and for the role that a tandem array of TPRs may have in mediating transcriptional repression.Keywords
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