The Identification of the Clinically-Important Sulphonamides

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Abstract
Summary: A scheme is described for the identification of all the sulphonamide drugs at present available in this country. The six stages of the process are simple and rapid operations involving no unusual reagents or apparatus: (i) purification of the crude material by charcoal treatment in acetone solution, followed by melting-point determination. (ii) preliminary identification as a sulphonamide compound by decomposition with soda-lime. (iii) detection of free primary amino group by condensation with furfural. (iv) simple crystal tests based on precipitation from ammonia solution by acetic acid vapour. (v) vanillin confirmatory test for sulphamerazine and sulphadimidine. (vi) mixed melting-point determination.
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