A 1H and 13C nmr study of the radiation-induced degradation products of 2′-deoxythymidine derivatives: N-(2′-deoxy-β-D-erythropentofuranosyl) formamide
- 15 December 1981
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 59 (24) , 3313-3318
- https://doi.org/10.1139/v81-490
Abstract
N-(2′-Deoxy-β-D-erythropentofuranosyl) formamide is an ionizing radiation-induced degradation product of 2′-deoxythymidine. This work describes a facile chemical synthesis of this molecule, and discusses the results of an 1H and 13C nmr study. The rotational barrier to cis–trans isomerization about the amide linkage is calculated, and details of the molecular conformation of the cis and trans isomers in aqueous solution are presented.This publication has 5 references indexed in Scilit:
- Proton magnetic resonance study of nucleosides, nucleotides, and dideoxynucleoside monophosphates containing asyn pyrimidine baseBiopolymers, 1981
- The solution conformational preferences of the sugar and sugar phosphate constituents of RNA and DNAJournal of the American Chemical Society, 1980
- Proton magnetic resonance studies of 2′-deoxynucleosides and nucleotides in the syn conformationCanadian Journal of Chemistry, 1978
- Thymine Fragment Damage Retained in the DNA Polynucleotide Chain after Gamma Irradiation in Aerated Solutions. IIRadiation Research, 1977
- Utilisation de l'effet overhauser des mesures de relaxation en RMN 1H, et des deplacements chimiques en RMN 13C dans l'etude de la conformation des amides—ITetrahedron, 1976