Subcellular localization of NAD(P)H oxidase(s) in human neutrophilic polymorphonuclear leucocytes
- 15 October 1978
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 176 (1) , 175-178
- https://doi.org/10.1042/bj1760175
Abstract
NADH and NADPH oxidase activities in a homogenate of human neutrophils co-sedimented in a linear sucrose density under velocity or isopycnic conditions of centrifugation. The position of these activities in the gradient does not correspond to any known subcellular granule or to the cell membrane fraction. The oxidase activities may reside in a unique granule that was previously unrecognized.This publication has 14 references indexed in Scilit:
- Analytical Subcellular Fractionation of Human Granulocytes with Special Reference to the Localization of Enzymes Involved in Microbicidal MechanismsClinical Science, 1977
- Comparison of NADH and NADPH oxidase activities in granules isolated from human polymorphonuclear leukocytes with a fluorometric assay.Journal of Clinical Investigation, 1977
- The oxidative killing mechanisms of the neutrophil.1977
- Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis.Journal of Clinical Investigation, 1975
- Defect in Pyridine Nucleotide Dependent Superoxide Production by a Particulate Fraction from the Granulocytes of Patients with Chronic Granulomatous DiseaseNew England Journal of Medicine, 1975
- [Peroxidase activity of neutrophil granules in two cases of congenital myeloperoxidase deficiency].1975
- An isotopic assay for NADPH oxidase activity and some characteristics of the enzyme from human polymorphonuclear leukocytes.Journal of Clinical Investigation, 1975
- Character of azurophil and specific granules purified from human polymorphonuclear leukocytes.1974
- NADPH oxidizing activity in rabbit polymorphonuclear leukocytes: Localization in azurophilic granulesBiochemical and Biophysical Research Communications, 1973
- THF EARLY STAGES OF ABSORPTION OF INJECTED HORSERADISH PEROXIDASE IN THE PROXIMAL TUBULES OF MOUSE KIDNEY: ULTRASTRUCTURAL CYTOCHEMISTRY BY A NEW TECHNIQUEJournal of Histochemistry & Cytochemistry, 1966