Benzodiazepine recognition sites on GABA receptors

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Abstract
A role of GABA in benzodiazepine actions is supported by the GABA stimulation of membrane-bound and soluble benzodiazepine receptors and preliminary evidence that GABA protects benzodiazepine receptors from heat inactivation. Calf brain GABA receptors labeled by 3H-muscimol have a benzodiazepine recognition site, as benzodiazepines, in proportion to their pharmacological activity, protect 3H-muscimol binding from inactivation by heat and the protein modifying reagent iodoacetamide. Benzodiazepines and GABA act at apparently distinct sites to protect benzodiazepine receptors from heat and iodoacetamide.