Azabenzomorphane and Related Compounds. VII. Synthesis of 1, 2, 3, 4, 5, 6-Hexahydro-2, 6-methanobenzo [d][1, 3] diazocine Derivatives
- 31 December 1964
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 13 (10) , 1220-1224
- https://doi.org/10.1248/cpb.13.1220
Abstract
In order to test the analgesic action of 1-methyl (XIa) and 1,3-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methanobenzo [d] [1,3] diazocine (Xlb) were synthesized from 1-methyl-4-carboxymethylcarbostyril (ID) as a starting material. Reductive cyclization of Xa and Xb with metallic Na in ethanol gave, respectively, the expected azabenzomorphane derivatives, XIa and Xlb. Furthermore, Ladenburg reduction of 1-methyl-4-carbamoylmethylcarbostyril (XII) also gave the above compound (XIa).This publication has 0 references indexed in Scilit: