Procaine, Lidocaine, and Ketamine Inhibit Histamine-lnduced Contracture of Guinea Pig Tracheal Muscle in Vitro
- 1 January 1978
- journal article
- Published by Wolters Kluwer Health in Anesthesia & Analgesia
- Vol. 57 (1) , 25???27-7
- https://doi.org/10.1213/00000539-197801000-00005
Abstract
In vitro experiments using guinea pig tracheal smooth muscle were performed to compare the relaxant properties of procaine, lidocaine, and ketamine following contracture induced by histamine. Procaine produced a spasmolytic effect in a dose-related manner. In the doses tested, relaxation induced by procaine was more pronounced than that produced by either lidocaine or ketamine, although the latter 2 drugs also had a significant spasmolytic effect.Keywords
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