Influence of renal denervation on urine concentration in awake and anaesthetized dogs

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Abstract
The role of renal nerves in urine concentration was studied in clearance experiments with unilaterally renal-denervated dogs prepared by surgical bladder division. Urine concentration was assessed under conditions of: stimulation of ADH [antidiuretic hormone] release by dehydration or barbiturate anesthesia; mannitol diuresis; and isotonic saline diuresis. Differences in .**GRAPHIC**. GFR [clearance studies free H2O reabsorption/glomerular filtration] between the intact and denervated kidney were not significant in any of the experimental groups. In dehydrated conscious dogs Uosm [urine osmolarity] of the intact kidney (939 .+-. 58 mmol/kg H2O) was significantly higher (P < 0.05) than that of the denervated organ (806 .+-. 51 mmol/kg H2O). In the intact kidney the medullary content of total solutes and Na/kg wet tissue was 684 .+-. 26 and 208 .+-. 12 mmol, respectively. This was significantly higher (P < 0.005) than corresponding values of 581 .+-. 23 and 171 .+-. 14 mmol/kg wet tissue measured in the denervated organ. A slight impairment of urine concentration (lower Uosm) in the denervated kidney of conscious dogs may depend on decreased medullary hypertonicity.