BIOENERGETICS IN CLINICAL MEDICINE .8. ADMINISTRATION OF COENZYME Q10 TO PATIENTS WITH ESSENTIAL HYPERTENSION

  • 1 January 1976
    • journal article
    • research article
    • Vol. 14  (4) , 721-727
Abstract
Coenzyme Q10 [CoQ10] was administered to 5 patients having essential hypertension and deficiencies of activity of succinate dehydrogenase-coenzyme Q10 reductase in leukocyte preparations ranging from 20-40%. For a 74 yr old male, the systolic pressure was reduced (P < 0.001), the diastolic pressure was reduced (P < 0.05), the specific activity of the CoQ10-enzyme was increased (P < 0.01). Four patients receiving CoQ10 for 3-5 mo. showed reductions (P < 0.05-P < 0.001) of systolic pressure, and 3 of these 4 showed reductions (P < 0.05-P < 0.01) of diastolic pressure. Initial deficiencies of enzyme activity were reduced (P < 0.01-0.05) in 2 patients. Three other patients did not show the high level of deficiency on treatment as initially observed. These effects of CoQ10 on the reduction of systolic and diastolic blood pressures, increase in CoQ10-enzyme activity, and reduction of CoQ10-deficiency are presumably due to improved bioenergetics through correction of a deficiency of CoQ10.

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