Comparison of Effect of Desoxycorticosterone Acetate and Cortisone Acetate on Rat Skeletal Muscle Electrolytes

Publisher Website
Google Scholar
Abstract
Analyses of skeletal muscle from adrenalectomized rats given cortisone acetate in amounts sufficient to induce severe hypertension revealed no impressive alteration in Na or K content 50152-50166 ENDOCRINE SYSTEM [Vol. 35] 4340 from normal, when dehydration of tissue was taken into account. In contrast, skeletal muscle from adrenalectomized rats given comparable amount of deoxycorticosterone acetate (DCA) and with comparable degrees of hypertension, showed, as anticipated, marked increase in Na and reduction in K content. In rats injected with cortisone, blood pressure and muscle electrolytes were comparable in groups maintained on a low Na diet and in groups with liberal Na intake. In contrast, in rats given DCA, both hypertension and shift in electrolyte content were dependent on high Na intake; neither was encountered when Na content of the diet was restricted. Muscles from adrenalectomized rats without steroid subsidy were normal in all respects in groups provided with liberal amounts of Na but were overhydrated and depleted of Na in the group sustaining Na restriction.

This publication has 0 references indexed in Scilit: