THE UREA CLEARANCE OF CATS WITH DIABETES INSIPIDUS
- 30 April 1938
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 122 (2) , 288-295
- https://doi.org/10.1152/ajplegacy.1938.122.2.288
Abstract
A persistent polyuria was produced in cats by surgical intervention in the hypothalamico-hypophyseal complex. The avg. urea clearance for normal cats is 14.3 cc. per sq. m. per min. and for operated animals 13.1 cc. per sq. m. per min. Pitressin acts on animals with this type of diabetes insipidus to reduce the minute urine vol., but it has no action on the normal urine flow of the unoperated cats. The urea clearance in both groups of animals is increased by this substance and by ant. pituitary substance. In normal and diabetic cats, urea clearance increases with increasing urine flows. This change is much less over the usual physiological ranges of urine flow than it is after administration of ant. pituitary.This publication has 0 references indexed in Scilit: