The Determination Of Morphine in Opium and Some of Its Galenical Preparations
- 1 September 1957
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 9 (1) , 914-928
- https://doi.org/10.1111/j.2042-7158.1957.tb12353.x
Abstract
A method of assay for morphine in opium depending upon precipitation of the dinitrophenylether with 1-fluoro-2:4-dinitrobenzene has been critically examined. The morphine is first separated from other alkaloids and extraneous matter by elution from an alumina column with an organic solvent and subsequent extraction with alkali. The method, which is rapid, has been applied to many galenical preparations and, in cases where the pharmacopoeial method based on the colorimetric nitroso reactions may give high results, figures in accordance with the expected values have been obtained.Keywords
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