Molecular Determinants ofListeria monocytogenesVirulence
- 1 October 2004
- journal article
- review article
- Published by Annual Reviews in Annual Review of Microbiology
- Vol. 58 (1) , 587-610
- https://doi.org/10.1146/annurev.micro.57.030502.090934
Abstract
Listeria monocytogenes is the etiological agent of listeriosis, a severe human foodborne infection characterized by gastroenteritis, meningitis, encephalitis, abortions, and perinatal infections. This gram-positive bacterium is a facultative intracellular pathogen that induces its own uptake into nonphagocytic cells and spreads from cell to cell using an actin-based motility process. This review covers both well-established and recent advances in the characterization of L. monocytogenes virulence determinants and their role in the pathophysiology of listeriosis.Keywords
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