INTERPUBIC LIGAMENT REGRESSION IN RELAXINTREATED VIRGIN AND PRIMIPAROUS, POST-PARTUM MICE†

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Abstract
Interpubic ligaments of post-partum mice undergo rapid involution whereas those produced in virgin mice by relaxin treatment persist for at least 104 days. High doses of thiouracil caused marked regression of the persistent ligament, probably by decreasing thyroid secretion. Thyroid hormone thus seems necessary for maintenance as well as growth (7, 8) of the intcrpubic ligament. In an attempt to explain the. involution of the interpubic ligament in pregnant mice and the persistence of the experimental ligament in nulliparous mice the following factors were studied as possibilities: (1) difference in hormonal balance of the post-partum mouse in contrast to the treated nulliparous mouse, (2) nursing versus non-suckling and (3) influence of residual long-acting estrogen prime. Although each of these factors appears to play a definite role in the involution or maintenance of the interpubic ligament, results of this study indicate that none are principally responsible.