Effects of Antibiotics on Adaptive Formation of Mitochondria in Yeast

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Abstract
The process of oxygen-induced completion of mitochondria from promitochondria in anaerobically grown Saccharomyces cerevisiae was studied by the addition of inhibitors before and after onset of aeration. Cycloheximide and chloramphenicol were used as protein synthesis inhibitors and actinomycin D and acriflavine were used in the analysis of contribution of RNA synthesis to mitochondrial formation. All the drugs tested, except for actinomycin D, were inhibitory to the process when added to the adaptation medium at the onset of the aeration, the effect being apparent after 30min. Actinomycin D exhibited no inhibition unless it was added 1–2hr prior to oxygen adaptation.

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