Isolation of morphine from toad skin.
- 1 March 1985
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 82 (6) , 1852-1854
- https://doi.org/10.1073/pnas.82.6.1852
Abstract
A nonpeptide opioid was found in toad skin and purified to homogeneity by using HPLC[high performance liquid chromatography] with electrochemical detection. A nonpeptide opioid also was detected in bovine brain and adrenals as well as rabbit and rat skin, by reversed-phase HPLC following Sephadex G-15 column chromatography. The material in toad skin was identical to morphine by immunological, pharmacological and physical chemical criteria.This publication has 10 references indexed in Scilit:
- Morphine in Cow and Human Milk: Could Dietary Morphine Constitute a Ligand for Specific Morphine (μ) Receptors?Science, 1981
- A non-peptide morphine-like compound from brainLife Sciences, 1981
- Determination of morphine and its major metabolite, morphine-3-glucuronide, in blood by high-performane liquid chromatography with electorchemical detectionJournal of Chromatography A, 1979
- Presence of a non-peptide morphine-like compound in human cerebrospinal fluidLife Sciences, 1978
- Binding of the endogenous nonpeptide morphine-like compound to opiate receptors.Proceedings of the National Academy of Sciences, 1977
- Antibodies as a means of isolating and characterizing biologically active substances: presence of a non-peptide, morphine-like compound in the central nervous system.Proceedings of the National Academy of Sciences, 1976
- Opiate Agonists and Antagonists Discriminated by Receptor Binding in BrainScience, 1973
- Quantitative determination of morphine in serum by radioimmunoassay.1971
- SENSITIVE FLUOROMETRIC ASSAY FOR MORPHINE IN PLASMA + BRAIN1964
- A Quantitative Immunochemical Measure of thePrimary Interaction Between I*BSA and AntibodyThe Journal of Infectious Diseases, 1958