Calcium-Stimulated Adenylyl Cyclases Required for Long-Term Potentiation in the Anterior Cingulate Cortex
- 1 July 2005
- journal article
- research article
- Published by American Physiological Society in Journal of Neurophysiology
- Vol. 94 (1) , 878-882
- https://doi.org/10.1152/jn.01205.2004
Abstract
Activity-dependent long-term potentiation (LTP) in the CNS is thought to be important in learning, memory, development, and persistent pain. Here, we report that NMDA receptor-dependent LTP is the major form of long-term plasticity in the anterior cingulate cortex (ACC). In addition to N -methyl-d-aspartate (NMDA) receptors, L-type voltage-gated calcium channels are also required for inducing LTP. Activation of calcium-stimulated adenylyl cyclase subtype 1 (AC1) is essential for the induction of LTP in ACC neurons, while AC8 subunit partially contributes to forskolin-induced potentiation. Our results suggest that calcium-stimulated cAMP-dependent signaling pathways play a critical role in cingulate LTP.Keywords
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