EFFECT OF SULFATED POLYSACCHARIDES ON BLOOD-BORNE PULMONARY METASTASIS IN RATS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 67  (6) , 849-856
Abstract
The inhibitory effect of sulfated polysaccharides on blood borne metastases was examined. As a model of blood borne metastases, the ascites form of hepatoma AH-109A was injected i.v. into Donryu rats. Examination of the pulmonary metastatic nodules 2 wk later showed inhibitory effects of the 5 sulfated polysaccharides tested. Xylan sulfate was the most inhibitory, and exerted its inhibitory effect when the tumor cells were in the pulmonary capillary beds. From the rapid disappearance of radioactivity from the lungs after injection of 125IUDR[125I-iododeoxyuridine]-labeled AH-109A cells, tumor cells seemed to be retained in the lungs for a short time. Measurement of the anticoagulative and fibrinolytic activities of 2 sulfated polysaccharides showed that the inhibitory effect of these compounds on blood borne metastases was proportional to their anticoagulative and fibrinolytic activities, xylan sulfate showing the highest activities. Sulfated polysaccharides may inhibit blood borne pulmonary metastases by inhibiting the lodging of tumor cells in the pulmonary capillary beds.

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