An inherited arginase deficiency in sheep erythrocytes

Abstract
Arginase (EC 3.5.3.1) catalyses the conversion of arginine to ornithine and urea, and is a key enzyme of the urea cycle. The enzyme is present in high activity in various mammalian red cells (Nishibe, 1973, 1974; Owczarczyk & Barej, 1975) and inherited arginase deficiencies have been found in two primate species (Shih et al. 1972; Terheggen, Lavinha & Colombo, 1972). The present paper describes an inherited arginase deficiency in the erythrocytes of certain sheep.

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