EXERTIONAL DYSPNEA: A PRIMARY COMPLAINT IN UNUSUAL CASES OF PROGRESSIVE MUSCULAR ATROPHY AND AMYOTROPHIC LATERAL SCLEROSIS

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Abstract
Primary muscular atrophy and amyotrophic lateral sclerosis may occasionally be associated with exertional dyspnea early in the course of the disease process before muscular atrophy and fasciculation in classic locations become evident. The clinician should consider these neurologic conditions in the differential diagnosis of dyspnea, especially if the cardiac and pulmonary findings are not compatible with the degree of respiratory disability. Studies of pulmonary function may reveal abnormalities that suggest insufficiency of the muscles of respiration rather than primary intrinsic pulmonary disease.

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