QUANTITATIVE INVESTIGATIONS ON THE INFLUENCE OF HORMONES ON ABSORPTION

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Abstract
The influence of adrenalin, thyroxin and insulin on the absorption of glucose from the gut was studied in Rana esculenta by perfusing the gut with isotonic glucose solution and by perfusing the blood vessels supplying the gut with Ringer''s with and without the hormones mentioned. Adrenalin increases sugar absorption in high concentrations (1:500,000 to 1:5,000,000) and decreases it in lower concentrations (1:10,000,000 to 1:25,000,000). The effects are independent of the vasoconstrictor effect. Thyroxin and insulin, which do not cause any vascular changes, increase sugar absorption. Small amounts of frog serum added to Ringer''s solution, although without effect on blood vessels and absorption, change considerably the effect of hormones on absorption. The effectiveness of adrenalin is increased and that of insulin decreased, whereas thyroxin remains unaffected. The permeability effects of the hormones are completely reversible.

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