The results of ingredient patch testing in contact dermatitis elicited by povidone‐iodine preparations

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Abstract
10 cases of contact dermatitis which began during the application of povidone‐iodine preparations were examined with patch tests using 2 kinds of povidone‐iodine preparations and their ingredients, i.e., povidone‐iodine, polyoxyethylene nonylphenyl ether and glycerin, and also the components of povidone‐iodine, i.e., iodine and polyvinylpyrrolidone. All 10 cases reacted positively to the povidone‐iodine preparations and povidone‐iodine, 3 out of the 10 to polyoxyethylene nonylphenyl ether, 1 out of the 9 tested to iodine, while no positive response was found to glycerin or polyvinylpyrrolidone. It was difficult to distinguish between allergic responses from irritation, as responses to patches of povidone‐iodine and its preparations usually include irritation at high frequencies. Based on comparison of results with a control group, however, those showing + or stronger reactions to 2% povidone‐iodine at days 3 to 5 were considered to be allergic. Thus, 4 out of the 10 cases were considered as sensitization to povidone‐iodine. Another 3 cases were found to be polyoxyethylene nonylphenyl ether sensitized, and another 1 iodine sensitized, while the patch test reactions of the other 2 were considered to have been elicited by irritation.

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