Characterization of Immune Escape Viruses from a Macaque Immunized with Live-Virus Vaccine and Challenged with Pathogenic SHIVKU-1
- 10 October 2000
- journal article
- research article
- Published by Mary Ann Liebert Inc in AIDS Research and Human Retroviruses
- Vol. 16 (15) , 1573-1580
- https://doi.org/10.1089/088922200750006092
Abstract
We characterized two immune escape viruses (SHIVKU-1/105w52 and SHIVKU-1/105w98) from a macaque immunized with ΔvpuΔnef SHIV-4 and challenged with pathogenic SHIVKU-1. This macaque developed neutralizing antibodies as well as virus-specific CTLs against the challenge virus. However, the two new viruses could not be neutralized by anti-SHIVKU-1-specific neutralizing antibodies and were poorly recognized by challenge virus-specific CTLs. Sequence analysis of the gene encoding gp120 revealed several mutations in the protein that might have contributed to the development of the immune-escape viruses.Keywords
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