A Histopathological Investigation on the Effects of the Bisphosphonate Alendronate on Resorptive Phase Following Mucoperiosteal Flap Surgery in the Mandible of Rats
- 1 May 2000
- journal article
- Published by Wiley in The Journal of Periodontology
- Vol. 71 (5) , 790-796
- https://doi.org/10.1902/jop.2000.71.5.790
Abstract
Background: The present study was designed to examine histopathologically whether local delivery of aminobisphosphonate (alendronate) could be effective in preventing the alveolar bone resorption associated with mucoperiosteal flaps.Methods: Following mucoperiosteal flap elevation in the molar region of the rat mandible, a surgical pellet soaked with aminobisphosphonate was locally applied on the exposed bone surface and covered by flap. The determined parameters with a semi‐quantitative subjective method for the histopathological evaluation were as follows: existing inflammatory cell infiltration of the related periodontal tissue; fibrotic component content and bundles of collagen fibers; the number and morphology of osteoclasts of the alveolar bone and interdental septum; existing resorption lacunae (osteoclast surfaces); and existing osteoblastic activity (forming surfaces).Results: The results showed that while there were no detectable statistically significant differences between the saline and alendronate‐treated groups on the existing inflammatory cell infiltration (ICI), number of osteoclasts, and osteoblastic activity, the results for the fibrotic and collagen component, osteoclast morphologies, and existing resorption lacunae were statistically significant.Conclusions: These results suggest that local application of the aminobisphosphonate alendronate can be used as an adjunct in therapy for reducing bone resorption following surgery. It can also be suggested for consideration that, even for the surgical approaches in dentistry where bone graft materials and/or dental implants are needed, using bisphosphonate may achieve a new dimension in periodontal therapy in the near future. J Periodontol 2000; 71:790‐796.Keywords
This publication has 37 references indexed in Scilit:
- Inhibitory effect of a bisphosphonate (risedronate) on experimental periodontities in ratsJournal of Periodontal Research, 1995
- Histomorphometrical analysis of the effects of the bisphosphonate alendronate on bone loss caused by experimental periodontitis in monkeysJournal of Periodontal Research, 1994
- Bisphosphonates act on rat bone resorption through the mediation of osteoblasts.Journal of Clinical Investigation, 1993
- Constitutive expression of osteoclast-stimulating activity by normal clonal osteoblast-like cells: effects of parathyroid hormone and 1,25- dihydroxyvitamin D3Endocrinology, 1992
- Bisphosphonate Space Measurement in Paget's Disease of Bone Treated with APDJournal of Bone and Mineral Research, 1992
- BisphosphonatesDrugs, 1991
- Structural requirements for the action of parathyroid hormone-related protein (PTHrP) on bone resorption by isolated osteoclastsJournal of Bone and Mineral Research, 1991
- Bisphosphonates in vitro specifically inhibit, among the hematopoietic series, the development of the mouse mononuclear phagocyte lineageJournal of Bone and Mineral Research, 1990
- The comparative effects of dichloromethylene diphosphonate (Cl2MDP) and ethane-1-hydroxy-1,1-diphosphonate (EHDP) on growth and modeling of the rat tibiaCalcified Tissue International, 1977