Beta-Hydrazinopropionitriles: A New Series of Osteolathyrogenic Agents for the Rat.

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Abstract
Summary A new series of compounds, β-hydrazinopropionitrile (BHPN) and certain of its methyl derivatives, have been found to have osteolathyrogenic properties for the rat. They cause skeletal deformities (spinal curvatures, periosteal new bone formation), increased saline-soluble collagen levels in sponge biopsy tissue, and occasional mild damage to the aortic media. Neither ruptured aortae nor gross dissecting aneurysms were observed. The most potent lathyrogens of this series are BHPN itself and α-methyl-BHPN. They appear to be comparable in lathyrogenicity to BAPN, but are more toxic than the latter. Less potent was β-methyl-BHPN with N1-methyl-BHPN being the least potent. N2-methyl-BHPN (methyl on terminal N of hydrazino group) was not tested.

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