Effect of Plasma Proteins on the Sieving Spectra of Hemofilters

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Abstract
A mixture of neutral maltodextrins with a continuous MW distribution from 340-120,000 daltons was used alone or in the presence of plasma to determine solute rejection by 4 hemofilters and the effect of plasma on such rejection. High pressure liquid chromatographic analyses were utilized to establish concentration ratios of feed and filtrate solutions over a wide MW range. At equal transmembrane velocities, the boundary layer-corrected rejection of each hemofilter was determined as a function of MW. The presence of plasma increased rejection by the Amicon Diafilter 30, the Hospial RP-6, and the Gambro FH202 hemofilters, but the Fresenius D-6 was virtually unaffected.