Selective Deficits in the Sense of Smell Caused by Chemical Modification of the Olfactory Epithelium

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Abstract
A chemically selective procedure for covalent modification of Schiff base-forming binding sites in proteins was demonstrated in vitro. In vivo studies showed that the some procedure produces a selective anosmia (odor blindness) when applied to the olfactory epithelia of experimental animals. Surgical experiments confirmed that the sense of smell is specifically affected. [Ambystoma tigrinum was used in this study.].