Depletion of CD4⁺ or CD8⁺ T-cells prevents Plasmodium berghei induced cerebral malaria in end-stage disease

1 January 1997

journal article
research article
Published by Cambridge University Press (CUP) in Parasitology

Vol. 114 (1) , 7-12
https://doi.org/10.1017/s0031182096008293

Abstract

The role of T-cells in development of experimental cerebral malaria was analysed in C57B1/6J and C57B1/10 mice infected with Plasmodium berghei K173 or Plasmodium berghei ANKA by treatment with anti-CD4 or anti-CD8 mAbs. Mice were protected against cerebral malaria (CM) when anti-CD4 or anti-CD8 mAbs were injected before or during infection. Even in mice in end-stage disease, i.e. with a body temperature below 35·5 °C, treatment with anti-CD4 or anti-CD8 antibodies or the combination protected against CM, whereas chloroquine treatment was completely ineffective in inhibiting further development of the cerebral syndrome.

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Depletion of CD4+ or CD8+ T-cells prevents Plasmodium berghei induced cerebral malaria in end-stage disease

Abstract

Keywords

Depletion of CD4⁺ or CD8⁺ T-cells prevents Plasmodium berghei induced cerebral malaria in end-stage disease