A versatile synthetic route to the anti-implantation agent, yuehchukene, and its analogues

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Abstract
A detailed study directed toward the development of a versatile synthetic route to the interesting dimeric natural product yuehchukene (1) and its epimer, 6a-epi-yuehchukene (2), has been completed. Due to the anti-implantation activity associated with 1, it was important to provide a synthetic strategy not only to 1, but to a family of yuehchukene analogues that, hopefully, would reveal superior chemical stability and (or) elevated biological activity. The experiments described herein and which utilize the readily available and inexpensive isophorone (6) satisfy these requirements. Key words: yuehchukene synthesis, yuehchukene analogues, anti-implantation activity.

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