Cloning and sequence analysis of complementary DNA encoding a precursor for chicken natriuretic peptide
- 25 March 1991
- journal article
- Published by Wiley in FEBS Letters
- Vol. 280 (2) , 357-362
- https://doi.org/10.1016/0014-5793(91)80331-v
Abstract
Chicken α-natriuretic peptide (α-chNP) has been identified in chicken heart, which showed higher homology to brain natriuretic peptide (BNP) than to atrial natriuretic peptide (ANP) [1]. Complementary DNA (cDNA) clone encoding a chNP precursor (pre-chNP) precursor (pre-chNP) was isolated from cardiac cDNA library and sequenced. Pre-chNP was 140-residue signal peptide at the N-terminus and α-chNP at the C-terminus, and did not exhibit high homology to poreine BNP except for the C-terminal region. However, a characteristic AT-rich nucleotide sequence commonly found in mammalian BNPs was also present in the 3′-untranslated region. Thus, chNP is concluded to be classified into the BNP-typKeywords
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