BILIRUBIN INHIBITS HEXOSE‐MONOPHOSPHATE SHUNT ACTIVITY OF PHAGOCYTOSING NEUTROPHILS
- 1 December 1977
- journal article
- research article
- Published by Wiley in Acta Paediatrica
- Vol. 66 (6) , 757-759
- https://doi.org/10.1111/j.1651-2227.1977.tb07985.x
Abstract
Neutrophil [human] hexose monophosphate (HMP) shunt activity was measured by the conversion of 14C-1-glucose to 14CO2 during ingestion of polystyrene latex particles. Unconjugated bilirubin at theconcentration of 1 .times. 105 M markedly inhibited HMP shunt activity. Since HMP shunt activity of neutrophils is an important prerequisite of microbicidal function, it is suggested that jaundiced newborns may be more susceptible to bacterial infections.Keywords
This publication has 14 references indexed in Scilit:
- CHARACTERISATION OF THE ENZYME DEFECT IN CHRONIC GRANULOMATOUS DISEASEThe Lancet, 1976
- Inhibitory effects of bilirubin on cellular immune responses in manThe Journal of Pediatrics, 1975
- Bilirubin: A multi‐site inhibitor of mitochondrial respirationFEBS Letters, 1972
- Respiration and glucose oxidation in human and guinea pig leukocytes: comparative studiesJournal of Clinical Investigation, 1970
- Effects of Bilirubin on Mitochondrial ReactionsJournal of Biological Chemistry, 1969
- Studies in kernicterus. II. The determinationof the saturation of serum albumin with bilirubinThe Journal of Pediatrics, 1969
- Deficiency of Reduced Nicotinamide-Adenine Dinucleotide Oxidase in Chronic Granulomatous DiseaseScience, 1968
- The Mechanism of Bilirubin Toxicity Studied with Purified Respiratory Enzyme and Tissue Culture Systems*Biochemistry, 1965
- STUDIES IN KERNICTERUS. I. THE PROTEIN BINDING OF BILIRUBIN*Journal of Clinical Investigation, 1959
- Bilirubin, an Uncoupler of Oxidative Phosphorylation in Isolated MitochondriaNature, 1956